State-of-the-art thrombosis prevention and treatment
نویسنده
چکیده
Thrombosis is the leading cause of death in developed countries, with arterial thrombosis presenting as myocardial infarction, stroke or peripheral arterial occlusion. Venous thromboembolism (VTE) is a major cause of mortality worldwide, despite some variations in prevalence of the disease [1]. While the incidence of VTE increases with aging, it is the leading cause of vascular morbidity in young adults. A multitude of risk factors can contribute to presentation of VTE [2]. This includes transient risk factors such as trauma, surgery, immobilization, long-haul flights, acute medical illness, hormonal therapy and pregnancy. Long-standing risk factors include chronic conditions such as congestive heart failure, chronic lung disease, inflammatory bowel disease and nephrotic syndrome. The discovery of thrombophilic risk factors opened a new era of genetic assessment of the predisposition for VTE with potential ability for better definition of the risk associated with transient risk factors. For example, hormonal therapy in women with thrombophilic risk factors, such as Factor V Leiden and the prothrombin gene polymorphism, multiply the risk for VTE [3]. While testing for thrombophilia is appealing, wider application has been hampered by equivocal cost-effectiveness analysis. A screening test for thrombophilia would be useful, and global assays such as the Protein C Global have been suggested in this regard [4]. In general, VTE is preventable by application of prophylactic measures. Applying early mobilization and physical measures such as elastic stockings and external pneumatic compression devices is useful. The current pharmacological approach is based on unfractionated, low-molecular-weight heparins (LMWH) and fondaparinux. Vitamin K
منابع مشابه
O3: Anxiety Psychopathology - Epidemiology and Burden of Disease: Problems and Solutions
The goal of this talk will be to familiarize the audience with the nature and prevalence of anxiety disorders and document their impact on society. Anxiety is the most common form of psychopathology affecting an estimated one in four people at some point during their lifetimes. In comparison to all types of diseases and injuries, a 2013 JAMA report indicated that anxiety disorders were the fift...
متن کاملThe effect of antipsychotics in the prevention and treatment of delirium in the elderly admitted to intensive care units: a systematic review
Introduction: The present study reviews published studies on the effects of antipsychotic use in the treatment of delirium in the elderly in order to determine the effect of antipsychotic drugs on the prevention and treatment of delirium in the elderly admitted to the intensive care unit and the possible side effects of these drugs in this group of patients. Method: The present review arti...
متن کاملFactors Affecting Treatment Adherence among HIV-Positive Patients in Eritrea
Strict adherence to anti-retroviral therapy (ART) is critical for sustained suppression of viral replication and prevention of opportunistic infections that often lead to disability or death. With increased availability of ART in recent years, achievement of optimal adherence has become very important in the management of HIV/AIDS in Eritrea. To assess the factors affecting adherence to ART of ...
متن کاملFactor V Leiden, MTHFR C677T and Prothrombin Gene Mutation G20210A in Iranian Patients with Venous Thrombosis
Background: Factor V Leiden, Prothrombin gene (G20210A) and MTHFR (C677T) polymorphism are the main biomarkers for evaluation of tendency for venous thromboembolism. We aimed to investigate the frequency of mutations in factor V Leiden, Prothrombin G20210A and MTHFR C677T and identify the genetic status for these mutations in patients with venous thrombosis. Methods: This study was carried out...
متن کاملIdentification and Prioritization of the State-of-the-Art Technologies in the Management of Iranian Public Libraries
Purpose: State-of-the-art technology refers to the best and latest technological advancement possible at a particular time. Today, public libraries play a key role in the various cultural and social spheres of society. Although various technologies can help to fulfill the basic roles of public libraries correctly and completely, their application in the context of these libraries undoubtedly fa...
متن کامل